Topic: Gangrene

Chris Knowles shares his background growing up around the music business, including memories of a nightclub owned by the Irish mob. He describes his involvement with the Boston hardcore punk scene in the early 1980s, specifically mentioning the bands Gangrene and Jerry's Kids. These experiences informed the "grim" atmosphere of his novel and his cynical view of the entertainment industry.

Dr. Jacobi explains why a podiatrist is uniquely qualified to discuss sugar, noting that the manifestations of high blood sugar often result in gangrene and amputations in the lower extremities. He describes his transition from a surgical focus to studying the biochemistry of what he calls a global pandemic. Currently, at least 350 million people worldwide are affected by diabetes and pre-diabetes.