46:28 It's hard to put into words, but this is very important. Viruses are obligate intracellular parasites that hijack cellular pathways to complete their life cycle So when you're talking about, well where's the virus? Show me the virus. There is no virus until the virus is fully implanted, until that information is fully planted in the host then the virus expresses Okay, in recent years an accumulating body of data has emerged suggesting that some viruses can also manipulate the vesicular trafficking machinery for their assembly egress and transmission. In other words where the endosome creates the exosome that exosome is designed to transport information from the endosome to a healthy cell in its normal process The viral information that has infected that endosome
47:27 is transported with the exosome, making the exosome itself the virus. This is very different than saying viruses don't exist! You see? This is very different than saying viruses are created in the human body... No no no no no that exosome could never have had that viral information, that it then transported and transferred into the next cell without it being infected in the first place. Exosomes are small membrane-bound vesicles that carry biological macromolecules from the site of production to target sites... Let's see let me get some important stuff here
48:07 Exosomal content of cells varies with the cell type that produces them as well as environmental factors that alter the normal state of a cell such as viral infection. Human DNA and RNA viruses alter the composition of host proteins, as well as incorporate their own viral proteins and other cargo into the secreted exosomes So you see where the either misinformation or fallacy is coming from. You know, these are very clear certain viruses deliver their genomes into intraluminal vesicles like exosomes which then serve as vehicles to transport the genome along the endocytic pathway to the nuclear periphery for replication
48:59 Moreover, endosomal vesicles can be diverted to the exocytic pathway and secreted as exosomes. Exosomes containing viral genomes can promote viral spread by infecting adjacent or in some cases distant permissive cells." So again, I'm not coming here and giving you my opinion which has no science or basis like this guy is. Like now a lot of people are parroting No, I actually said okay maybe that's true. Maybe this guy has got a theory so i'm going to go look and I pulled up acting completely in neutrality like I always do.
49:42 Alright, and here's a perfect example. Viral infection by exosome mimicry So of course here's a guy who has been fooled by the mimicry Yeah that makes sense I can even forgive him for being a useful idiot or useful innocent if the exosomes looks exactly like Or is a mimicry what the exosome normally does, yeah that makes sense. Through the HIV-CR1NPC1 pathway, exosomes play a significant role in cell to cell communications. Viruses hijack exosomes hiding in their lumen to avoid immune recognition and enter the cell however how exosomes deliver their cargo into the cytoplasm still remains unknown
50:31 So you've got this wealth of information. There's nothing in the scientific literature that I can find that shows anything other than this, so if i can find this without any credentials without any little letters behind my name and I can deliver to you all of this information You're telling me that this guy who claims an MIT background, which I can't find. Who claims all these credentials which i can't find and nobody else can seem to find... you're telling me he can't find this? Well, I think part of the problem with playing devil's advocate is that